Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192278" target="_blank" >RIV/00216208:11110/13:10192278 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1042/CS20120661" target="_blank" >http://dx.doi.org/10.1042/CS20120661</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/CS20120661" target="_blank" >10.1042/CS20120661</a>

Result language

angličtina

Original language name

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

Original language description

Recent epidemiological and clinical data show protection from CVD, all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n = 59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n = 40) was investigated to further support the presented human data. GS subjects had significantly (P < 0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low-

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Science

ISSN

0143-5221

e-ISSN

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Volume of the periodical

125

Issue of the periodical within the volume

5-6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

257-264

UT code for WoS article

000322504400004

EID of the result in the Scopus database

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