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Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193024" target="_blank" >RIV/00216208:11110/13:10193024 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11140/13:10193024 RIV/00669806:_____/13:10193024 RIV/00064165:_____/13:10193024

  • Result on the web

    <a href="http://dx.doi.org/10.3109/01902148.2012.737404" target="_blank" >http://dx.doi.org/10.3109/01902148.2012.737404</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3109/01902148.2012.737404" target="_blank" >10.3109/01902148.2012.737404</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs

  • Original language description

    The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-alpha, MIP-1 beta, nitrites/nitrates, and inducible nitricoxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-alpha increased significantly in group III during the second and third hour (P = .01). Conc

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Experimental Lung Research

  • ISSN

    0190-2148

  • e-ISSN

  • Volume of the periodical

    39

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    8

  • Pages from-to

    1-8

  • UT code for WoS article

    000313682100001

  • EID of the result in the Scopus database