Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193024" target="_blank" >RIV/00216208:11110/13:10193024 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/13:10193024 RIV/00669806:_____/13:10193024 RIV/00064165:_____/13:10193024
Result on the web
<a href="http://dx.doi.org/10.3109/01902148.2012.737404" target="_blank" >http://dx.doi.org/10.3109/01902148.2012.737404</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/01902148.2012.737404" target="_blank" >10.3109/01902148.2012.737404</a>
Alternative languages
Result language
angličtina
Original language name
Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs
Original language description
The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-alpha, MIP-1 beta, nitrites/nitrates, and inducible nitricoxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-alpha increased significantly in group III during the second and third hour (P = .01). Conc
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Lung Research
ISSN
0190-2148
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
1-8
UT code for WoS article
000313682100001
EID of the result in the Scopus database
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