Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193131" target="_blank" >RIV/00216208:11110/13:10193131 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00392092 RIV/00023001:_____/13:00058533 RIV/00064165:_____/13:10193131
Result on the web
<a href="http://dx.doi.org/10.1093/ajh/hps015" target="_blank" >http://dx.doi.org/10.1093/ajh/hps015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ajh/hps015" target="_blank" >10.1093/ajh/hps015</a>

Result language
angličtina
Original language name
Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats
Original language description
BACKGROUND The role of folate deficiency and associated hyperhomocysteinemia in the pathogenesis of metabolic syndrome is not fully established. In the current study, we analyzed the role of folate deficiency in pathogenesis of the metabolic syndrome inthe spontaneously hypertensive rat (SHR). METHODS Metabolic and hemodynamic traits were assessed in SHR/Ola rats fed either folate-deficient or control diet for 4 weeks starting at the age of 3 months. RESULTS Compared to SHRs fed a folate-replete diet,SHRs fed a folate-deficient diet showed significantly reduced serum folate (104 +/- 5 vs. 11 +/- 1 nmol/L, P < 0.0005) and urinary folate excretion (4.3 +/- 0.6 vs. 1.2 +/- 0.1 nmol/16 h, P < 0.0005) together with a near 3-fold increase in plasma total homocysteine concentration (4.5 +/- 0.1 vs 13.1 +/- 0.7 mu mol/L, P < 0.0005), ectopic fat accumulation in liver, and impaired glucose tolerance. Folate deficiency also increased systolic blood pressure by approximately 15 mm Hg (P < 0.01)
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)