Associations Between Cardiac Fibrosis and Permanent Atrial Fibrillation in Advanced Heart Failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193323" target="_blank" >RIV/00216208:11110/13:10193323 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/13:00058664

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/62/62_247.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/62/62_247.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Associations Between Cardiac Fibrosis and Permanent Atrial Fibrillation in Advanced Heart Failure

Original language description

Atrial fibrosis is considered as the basis in the development of long-standing atrial fibrillation (AF). However, in advanced heart failure (HF), the independent role of fibrosis for AF development is less clear since HF itself leads to atrial scarring.Our study aimed to differentiate patients with AF from patients without AF in a population consisting of patients with advanced HF. Myocardial samples from the right atrial and the left ventricular wall were obtained during heart transplantation from theexplanted hearts of 21 male patients with advanced HF. Long-standing AF was present in 10 of them and the remaining 11 patients served as sinus rhythm controls. Echocardiographic and hemodynamic measurements were recorded prior to heart transplantation.Collagen volume fraction (CVF), transforming growth factor-beta (TGF-beta), and connective tissue growth factor (CTGF) expression in myocardial specimens were assessed histologically and immunohistochemically. The groups were well matche

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

247-255

UT code for WoS article

000321322900003

EID of the result in the Scopus database

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