Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193340" target="_blank" >RIV/00216208:11110/13:10193340 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11410/13:10193340 RIV/00064165:_____/13:10193340
Result on the web
<a href="http://fb.cuni.cz/file/5706/FB2013A0033.pdf" target="_blank" >http://fb.cuni.cz/file/5706/FB2013A0033.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders
Original language description
Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat HO1 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higherin patients compared to controls (P LESS-THAN OR EQUAL TO 0.001; P LESS-THAN OR EQUAL TO 0.002; P LESS-THAN OR EQUAL TO 0.001), 2) the L/L genotype of GT promoter repeats (L < 25 GT repeats, S < 25 GT repeats) in the patients was associa
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Project
<a href="/en/project/NT14094" target="_blank" >NT14094: GENETIC AND ENVIRONMENTAL FACTORS IN EATING DISORDERS. A NEW GENETIC APPROACHES AND ENDOPHENOTYPES</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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