A common biological basis of obesity and nicotine addiction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193436" target="_blank" >RIV/00216208:11110/13:10193436 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/13:33144515 RIV/61988987:17110/13:A1601AW7
Result on the web
<a href="http://dx.doi.org/10.1038/tp.2013.81" target="_blank" >http://dx.doi.org/10.1038/tp.2013.81</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/tp.2013.81" target="_blank" >10.1038/tp.2013.81</a>

Result language
angličtina
Original language name
A common biological basis of obesity and nicotine addiction
Original language description
Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism.However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI(r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 x 10-7). These findings replicate in a second large data set (N=127 274, thereof 76 242 smokers) for both SI (P=1.2 x 10-5) and CPD (P=9.3 x 10-5). Notably, the variant most strongly associate
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FM - Hygiene
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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