Modeling tumorigenesis in Drosophila: Current Advances and Future Perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195048" target="_blank" >RIV/00216208:11110/13:10195048 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5772/55686" target="_blank" >http://dx.doi.org/10.5772/55686</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/55686" target="_blank" >10.5772/55686</a>
Alternative languages
Result language
angličtina
Original language name
Modeling tumorigenesis in Drosophila: Current Advances and Future Perspectives
Original language description
Cancer is essentially considered as a genetic disease caused by the accumulation of multiple genetic or epigenetic lesions in tumor-suppressor genes and oncogenes [1]. Although the notion that retinoblastoma could be an inherited disease was already formulated at the end of the 19th Century a solid genetic basis was established with the discovery of both proto-oncogenes, whose gain-of function mutations or altered expression is associated with the cancerous state, and tumor suppressor genes (TSGs), whose inactivation releases the "brakes" inhibiting cell proliferation. Analysis of both proto-oncogenes and TSGs revealed also that cancer results from an alteration of the normal pathway of cell fate and differentiation. The hallmarks of cancer, as laid down by Hanahan and Weinberg to explain the complex biology of cancer, comprise six major developmental changes taking successively place in human tumors. These cancer "characteristics" include sustained proliferative signaling, evasion of
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP302%2F11%2F1640" target="_blank" >GAP302/11/1640: Morphological features and molecular determinants of apocrine secretion</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Future Aspects of Tumor Suppressor Gene
ISBN
978-953-51-1063-7
Number of pages of the result
29
Pages from-to
98-127
Number of pages of the book
221
Publisher name
InTech
Place of publication
Rijeka, Croatia
UT code for WoS chapter
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