Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195073" target="_blank" >RIV/00216208:11110/13:10195073 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00395434 RIV/00023001:_____/13:00058654 RIV/00064203:_____/13:10195073
Result on the web
<a href="http://dx.doi.org/10.1016/j.exger.2013.04.012" target="_blank" >http://dx.doi.org/10.1016/j.exger.2013.04.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.exger.2013.04.012" target="_blank" >10.1016/j.exger.2013.04.012</a>

Result language
angličtina
Original language name
Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy
Original language description
In humans, aging is accompanied by the deterioration of the hearing function - presbycusis. The major etiology for presbycusis is the loss of hair cells in the inner ear; less well known are changes in the central auditory system. Therefore, we used 1 Hmagnetic resonance spectroscopy at 3 T tomograph to examine metabolite levels in the auditory cortex of three groups of subjects: young healthy subjects less than 30 years old and subjects older than 65 years either with mild presbycusis corresponding totheir age or with expressed presbycusis. Hearing function in all subjects was examined by pure tone audiometry (125-16000 Hz). Significant differences were found in the concentrations of glutamate and N-acetylaspartate, with lower levels in aged subjects. Lactate was particularly increased in subjects with expressed presbycusis. Significant differences were not found in other metabolites, including GABA, between young and elderly subjects. The results demonstrate that the age-related ch
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/GAP304%2F10%2F1872" target="_blank" >GAP304/10/1872: Influence of aging on the auditory cortex in man - a MR study</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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