DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195209" target="_blank" >RIV/00216208:11110/13:10195209 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/13:00010674 RIV/00064165:_____/13:10195209
Result on the web
<a href="http://dx.doi.org/10.1186/1756-8722-6-9" target="_blank" >http://dx.doi.org/10.1186/1756-8722-6-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1756-8722-6-9" target="_blank" >10.1186/1756-8722-6-9</a>
Alternative languages
Result language
angličtina
Original language name
DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population
Original language description
Background: Interactions between genetic variants and risk factors in myelodysplastic syndromes are poorly understood. In this case-control study, we analyzed 1 421 single nucleotide polymorphisms in 408 genes involved in cancer-related pathways in 198 patients and 292 controls. Methods: The Illumina SNP Cancer Panel was used for genotyping of samples. The chi-squared, p-values, odds ratios and upper and lower limits of the 95% confidence interval were calculated for all the SNPs that passed the qualitycontrol filtering. Results: Gene-based analysis showed nine candidate single nucleotide polymorphisms significantly associated with the disease susceptibility (q-value < 0.05). Four of these polymorphisms were located in oxidative damage/DNA repair genes (LIG1, RAD52, MSH3 and GPX3), which may play important roles in the pathobiology of myelodysplastic syndromes. Two of nine candidate polymorphisms were located in transmembrane transporters (ABCB1 and SLC4A2), contributing to individual
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13899" target="_blank" >NT13899: THE NEXT GENERATION SEQUENCING AS A TOOL OF PERSONAL MEDICINE IN PATIENTS WITH MYELODYSPLASTIC SYNDROME AND CHRONIC MYELOID LEUKEMIA.</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Hematology and Oncology
ISSN
1756-8722
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
Jan 22
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
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UT code for WoS article
000315292400001
EID of the result in the Scopus database
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