The involvement of heme oxygenase 1 but not nitric oxide synthase 2 in a hepatoprotective action of quercetin in lipopolysaccharide-induced hepatotoxicity of D-galactosamine sensitized rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195513" target="_blank" >RIV/00216208:11110/13:10195513 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.fitote.2013.03.016" target="_blank" >http://dx.doi.org/10.1016/j.fitote.2013.03.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2013.03.016" target="_blank" >10.1016/j.fitote.2013.03.016</a>

Result language
angličtina
Original language name
The involvement of heme oxygenase 1 but not nitric oxide synthase 2 in a hepatoprotective action of quercetin in lipopolysaccharide-induced hepatotoxicity of D-galactosamine sensitized rats
Original language description
The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure. Liver insult was induced by in vivo administration of D-galactosamine (D-GaIN, 400 mg/kg, i.p.) and lipopolysaccharide (LPS, 10 mu g/kg, i.p.). The effects of quercetin (50 mg/kg, i.p) on D-GaIN toxicity was evaluated by standard biochemical, RT-PCR and Western blot methods. Administration of D-GaIN/LPS combination resulted in significantly higher plasma levels of aminotransferases, as well as increased mRNA and protein expressions of both HO-1 and NOS-2 enzymes. Quercetin exhibited cytoprotective effects on the liver, as evidenced by decreased aminotransferase plasma levels. Additionally, quercetin treatment in D-GaIN/LPS treated rats significantly increased HO-1 mRNA and its protein expressions. On the contrary, quercetin did not exhibit any significant effects on the levels
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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