Proteinuria and Hypertension in Patients Treated with Inhibitors of the VEGF Signalling Pathway - Incidence, Mechanisms and Management

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195716" target="_blank" >RIV/00216208:11110/13:10195716 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10195716

Result on the web

<a href="http://fb.cuni.cz/file/5667/FB2013A0002.pdf" target="_blank" >http://fb.cuni.cz/file/5667/FB2013A0002.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Proteinuria and Hypertension in Patients Treated with Inhibitors of the VEGF Signalling Pathway - Incidence, Mechanisms and Management

Original language description

Anti-VEGF therapy dramatically improved the outcome of patients with renal cancer and other advanced malignancies, but may be complicated by proteinuria and hypertension. VEGF is indispensable for the normal development of glomerulus and preservation ofglomerular filtration barrier. Interference with its action may result in damage to glomerular endothelial cells and (in severe cases) in renal thrombotic microangiopathy. Blood pressure and proteinuria (using dipstick) should be assessed in all patientsbefore starting anti-VEGF therapy and regularly monitored during the treatment. Patients with severe proteinuria and/or impaired renal function should be referred to the nephrologist for further work-up. Hypertension caused by anti-VEGF therapy can be effectively treated; progression of proteinuria and/or renal dysfunction may require tapering, or even withdrawal of anti-VEGF treatment.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

15-25

UT code for WoS article

000326215200002

EID of the result in the Scopus database

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