Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10196298" target="_blank" >RIV/00216208:11110/13:10196298 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/13:10196298
Result on the web
<a href="http://dx.doi.org/10.1016/S0140-6736(12)61963-1" target="_blank" >http://dx.doi.org/10.1016/S0140-6736(12)61963-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0140-6736(12)61963-1" target="_blank" >10.1016/S0140-6736(12)61963-1</a>
Alternative languages
Result language
angličtina
Original language name
Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial
Original language description
Background For women with oestrogen receptor (ER)-positive early breast cancer, treatment with tamoxifen for 5 years substantially reduces the breast cancer mortality rate throughout the first 15 years after diagnosis. We aimed to assess the further effects of continuing tamoxifen to 10 years instead of stopping at 5 years.Interpretation For women with ER-positive disease, continuing tamoxifen to 10 years rather than stopping at 5 years produces a further reduction in recurrence and mortality, particularly after year 10. These results, taken together with results from previous trials of 5 years of tamoxifen treatment versus none, suggest that 10 years of tamoxifen treatment can approximately halve breast cancer mortality during the second decade afterdiagnosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Lancet
ISSN
0140-6736
e-ISSN
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Volume of the periodical
381
Issue of the periodical within the volume
9869
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
805-816
UT code for WoS article
000316060600030
EID of the result in the Scopus database
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