All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Genetics of pheochromocytoma and paraganglioma syndromes: new advances and future treatment options

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10209747" target="_blank" >RIV/00216208:11110/13:10209747 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/13:10209747 RIV/00064203:_____/13:10209747 RIV/00064165:_____/13:10209747

  • Result on the web

    <a href="http://dx.doi.org/10.1097/MED.0b013e32835fcc45" target="_blank" >http://dx.doi.org/10.1097/MED.0b013e32835fcc45</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/MED.0b013e32835fcc45" target="_blank" >10.1097/MED.0b013e32835fcc45</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genetics of pheochromocytoma and paraganglioma syndromes: new advances and future treatment options

  • Original language description

    Purpose of review To summarize the recent advances in the genetics of pheochromocytoma and paraganglioma (PHEO/PGL), focusing on the new susceptibility genes and dividing PHEOs/PGLs into two groups based on their transcription profile. Recent findings Recently, TMEM127, MYC-associated factor X, and hypoxia-inducible factor (HIF) 2 alpha have been described in the pathogenesis of PHEOs/PGLs. Thus, now about 30-40% of these tumors are linked to the germline mutations, which also include mutations in the VHL, RET, NF1, SDHx, and SDHAF2 genes. Furthermore, PHEOs/PGLs have been divided into two groups, cluster 1 (SDHx/VHL) and cluster 2 (RET/NF1), based on the transcription profile revealed by genome-wide expression microarray analysis. Summary PHEOs/PGLs are the most inherited tumors among (neuro) endocrine tumors. Future approaches in genetics, including whole-genome sequencing, will allow the discovery of additional PHEO/PGL susceptibility genes. The current division of PHEOs/PGLs into c

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Opinion in Endocrinology, Diabetes and Obesity

  • ISSN

    1752-296X

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    186-191

  • UT code for WoS article

    000318024200005

  • EID of the result in the Scopus database