Lack of Replication of Seven Pancreatic Cancer Susceptibility Loci Identified in Two Asian Populations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10210038" target="_blank" >RIV/00216208:11110/13:10210038 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00396315 RIV/75010330:_____/13:00010089
Result on the web
<a href="http://dx.doi.org/10.1158/1055-9965.EPI-12-1182" target="_blank" >http://dx.doi.org/10.1158/1055-9965.EPI-12-1182</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1158/1055-9965.EPI-12-1182" target="_blank" >10.1158/1055-9965.EPI-12-1182</a>
Alternative languages
Result language
angličtina
Original language name
Lack of Replication of Seven Pancreatic Cancer Susceptibility Loci Identified in Two Asian Populations
Original language description
Background: Two recent genome-wide association studies (GWAS) of pancreatic ductal adenocarcinoma (PDAC), conducted, respectively, in a Japanese and in a Chinese population, identified eight novel loci affecting PDAC risk. Methods: We attempted to replicate the novel loci in a series of PDACs and healthy controls of European ancestry in the context of the newly formed PANcreatic Disease ReseArch (PANDoRA) consortium. We genotyped seven single-nucleotide polymorphisms (SNP): rs12413624, rs1547374, rs372883, rs5768709, rs6464375, rs708224, rs9502893 (one SNP identified in the Chinese GWAS is not polymorphic in Caucasians) in 1,299 PDAC cases and 2,884 controls. We also attempted stratified analysis considering the different stages of the disease and addressed the possible involvement of the selected SNPs on the survival of patients. Results: None of the SNPs were significantly associated with PDAC risk if considering the overall population of the consortium. When stratifying for country
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Epidemiology Biomarkers and Prevention
ISSN
1055-9965
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
320-323
UT code for WoS article
000314700800018
EID of the result in the Scopus database
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