Different cytokine production and toll-like receptor expression induced by heat-killed invasive and carrier strains of Neisseria meningitidis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10194775" target="_blank" >RIV/00216208:11110/14:10194775 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/apm.12062" target="_blank" >http://dx.doi.org/10.1111/apm.12062</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apm.12062" target="_blank" >10.1111/apm.12062</a>
Alternative languages
Result language
angličtina
Original language name
Different cytokine production and toll-like receptor expression induced by heat-killed invasive and carrier strains of Neisseria meningitidis
Original language description
Neisseria meningitidis may cause severe invasive disease. The carriage state of the pathogen is common, and the reasons underlying why the infection becomes invasive are not fully understood. The aim of this study was to compare the differences between invasive and carrier strains in the activation of innate immunity. The monocyte expression of TLR2, TLR4, CD14, and HLA-DR, cytokine production, and the granulocyte oxidative burst were analyzed after in vitro stimulation by heat-killed invasive (n=14) and carrier (n=9) strains of N. meningitidis. The expression of the cell surface markers in monocytes, the oxidative burst, and cytokine concentrations were measured using flow cytometry. Carrier strains stimulated a higher production of inflammatory cytokines and oxidative burst in granulocytes than invasive strains (all p<0.001), whereas invasive strains significantly up-regulated TLR2, TLR4 (p<0.001), and CD14 (p<0.01) expression on monocytes. Conversely, the monocyte expression of HLA-
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
ISSN
0903-4641
e-ISSN
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Volume of the periodical
122
Issue of the periodical within the volume
1
Country of publishing house
DK - DENMARK
Number of pages
9
Pages from-to
33-41
UT code for WoS article
000328909100005
EID of the result in the Scopus database
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