A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10218646" target="_blank" >RIV/00216208:11110/14:10218646 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/14:00217849 RIV/00064165:_____/14:10218646
Result on the web
<a href="http://dx.doi.org/10.1007/s00702-014-1158-6" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1158-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00702-014-1158-6" target="_blank" >10.1007/s00702-014-1158-6</a>

Result language
angličtina
Original language name
A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse
Original language description
A distinctive alteration of speech has been reported in patients suffering from ephedrone-induced parkinsonism. However, an objective assessment of dysarthria has not been performed in ephedrone users. We studied 28 young Caucasian men from Georgia witha previous history of ephedrone abuse and compared them to 25 age-matched healthy controls. Speech examination, brain MRI, and NNIPPS-Parkinson plus scale were performed in all patients. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analyses of 15 speech dimensions. We revealed a distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedrone-induced parkinsonism. According to acoustic analyses, all patients presented at least one affected speech dimension, whereas dysarthria was moderate in 43 % and severe in 36 % of patients. Further findings indicated relationships
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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