Microvessel density of mantle cell lymphoma. A retrospective study of its prognostic role and the correlation with the Ki-67 and the mantle cell lymphoma international prognostic index in 177 cases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10271636" target="_blank" >RIV/00216208:11110/14:10271636 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/14:00080024 RIV/00216208:11130/14:10271636 RIV/00216208:11150/14:10271636 RIV/00216208:11140/14:10271636 and 5 more
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs00428-014-1632-4" target="_blank" >http://link.springer.com/article/10.1007%2Fs00428-014-1632-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-014-1632-4" target="_blank" >10.1007/s00428-014-1632-4</a>

Result language
angličtina
Original language name
Microvessel density of mantle cell lymphoma. A retrospective study of its prognostic role and the correlation with the Ki-67 and the mantle cell lymphoma international prognostic index in 177 cases
Original language description
The clinical course and therapy of mantle cell lymphoma (MCL) are heterogeneous and often unsatisfactory. Prognostic factors are needed to stratify the patients. Microvessel density (MVD) has prognostic significance in some malignancies. There is littleinformation about the vasculature of MCL, although some antiangiogenic drugs are in use. We studied MVD using systematic uniform random sampling and unbiased counting frames in immunohistochemical reactions with anti-CD34 antibody in pretherapeutic extramedullary MCL samples of 177 patients. We analyzed the relationship of MVD to overall survival (OS) and progression-free survival (PFS), as well as to proliferative activity (Ki-67), mantle cell lymphoma prognostic index (MIPI), morphological variant, pattern of growth, and localization. MVD varied widely: range 54.6-503.6 vessels/ mm2, median 158.2 vessels/mm2. Higher MVD was associated with bone marrow infiltration at the time of iagnosis (P= .001). High MVD was associated with signifi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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