Developmental determinants of cardiac sensitivity to hypoxia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272164" target="_blank" >RIV/00216208:11110/14:10272164 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00434523
Result on the web
<a href="http://dx.doi.org/10.1139/cjpp-2013-0498" target="_blank" >http://dx.doi.org/10.1139/cjpp-2013-0498</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1139/cjpp-2013-0498" target="_blank" >10.1139/cjpp-2013-0498</a>
Alternative languages
Result language
angličtina
Original language name
Developmental determinants of cardiac sensitivity to hypoxia
Original language description
Cardiac sensitivity to oxygen deprivation changes significantly during ontogenetic development. However, the mechanisms for the higher tolerance of the immature heart, possibilities of protection, and the potential impact of perinatal hypoxia on cardiactolerance to oxygen deprivation in adults have not yet been satisfactorily clarified. The hypoxic tolerance of an isolated rat heart showed a triphasic pattern: significant decrease from postnatal day 1 to 7, followed by increase to the weaning period, and final decline to adulthood. We have observed significant ontogenetic changes in mitochondrial oxidative phosphorylation and mitochondrial membrane potential, as well as in the role of the mitochondrial permeability transition pores in myocardial injury. These results support the hypothesis that cardiac mitochondria are deeply involved in the regulation of cardiac tolerance to oxygen deprivation during ontogenetic development. Ischemic preconditioning failed to increase tolerance to ox
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Canadian Journal of Physiology and Pharmacology
ISSN
0008-4212
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
7
Country of publishing house
CA - CANADA
Number of pages
9
Pages from-to
566-574
UT code for WoS article
000338713600008
EID of the result in the Scopus database
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