Partial deficiency of HIF-1 alpha stimulates pathological cardiac changes in streptozotocin-induced diabetic mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272171" target="_blank" >RIV/00216208:11110/14:10272171 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/14:00433865 RIV/67985823:_____/14:00433865

Result on the web

<a href="http://dx.doi.org/10.1186/1472-6823-14-11" target="_blank" >http://dx.doi.org/10.1186/1472-6823-14-11</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1472-6823-14-11" target="_blank" >10.1186/1472-6823-14-11</a>

Result language

angličtina

Original language name

Partial deficiency of HIF-1 alpha stimulates pathological cardiac changes in streptozotocin-induced diabetic mice

Original language description

Background: Diabetic cardiomyopathy is associated with a number of functional and structural pathological changes such as left ventricular dysfunction, cardiac remodeling, and apoptosis. The primary cause of diabetic cardiomyopathy is hyperglycemia, themetabolic hallmark of diabetes. Recent studies have shown that a diabetic environment suppresses hypoxia-inducible factor (HIF)-1 alpha protein stability and function. The aim of this study was to analyze the functional role of HIF-1 alpha in the development of diabetic cardiomyopathy. We have hypothesized that the partial deficiency of HIF-1 alpha may compromise cardiac responses under diabetic conditions and increase susceptibility to diabetic cardiomyopathy. Methods: Diabetes was induced by streptozotocin in wild type (Wt) and heterozygous Hif1a knock-out (Hif1a(+/-)) mice. Echocardiographic evaluations of left ventricular functional parameters, expression analyses by qPCR and Western blot, and cardiac histopathology assessments were

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Endocrine Disorders

ISSN

1472-6823

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

February

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000334624800001

EID of the result in the Scopus database

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