Hypothalamo-pituitary-adrenal axis, glucose metabolism and TNF-alpha in narcolepsy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272222" target="_blank" >RIV/00216208:11110/14:10272222 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10272222
Result on the web
<a href="http://dx.doi.org/10.1111/jsr.12138" target="_blank" >http://dx.doi.org/10.1111/jsr.12138</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jsr.12138" target="_blank" >10.1111/jsr.12138</a>

Result language
angličtina
Original language name
Hypothalamo-pituitary-adrenal axis, glucose metabolism and TNF-alpha in narcolepsy
Original language description
Narcolepsy with cataplexy is caused by a deficiency in the production of hypocretin/orexin, which regulates sleep and wakefulness, and also influences appetite, neuroendocrine functions and metabolism. In this case-control study, 11 patients with narcolepsy with cataplexy and 11 healthy adults underwent an oral glucose tolerance test, and dexamethasone suppression/corticotropin-releasing hormone stimulation test. The average age of patients and controls was 35.1 +/- 13.2 and 41.0 +/- 2.9 years, respectively, body mass index was 28.1 +/- 6.6 and 25.5 +/- 4.7 kg m(-2). We did not find evidence of a significantly increased prevalence of disturbed glucose tolerance in patients with narcolepsy. After hypothalamo-pituitary-adrenal axis suppression, the number of non-suppressors did not differ between the groups, indicating normal negative feedback sensitivity. The level of cortisol after dexamethasone suppression was significantly lower in patients with narcolepsy, suggesting a slight basal
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT13238" target="_blank" >NT13238: Narcolepsy – clinical picture, pathophysiology, ageing, comorbidities and physical activity regimen</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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