Antiproliferative effects of carbon monoxide on pancreatic cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10281836" target="_blank" >RIV/00216208:11110/14:10281836 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/14:43897514 RIV/00064165:_____/14:10281836

Result on the web

<a href="http://dx.doi.org/10.1016/j.dld.2013.12.007" target="_blank" >http://dx.doi.org/10.1016/j.dld.2013.12.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dld.2013.12.007" target="_blank" >10.1016/j.dld.2013.12.007</a>

Result language

angličtina

Original language name

Antiproliferative effects of carbon monoxide on pancreatic cancer

Original language description

Background: Carbon monoxide, the gaseous product of heme oxygenase, is a signalling molecule with a broad spectrum of biological activities. The aim of this study was to investigate the effects of carbon monoxide on proliferation of human pancreatic cancer. Methods: In vitro studies were performed on human pancreatic cancer cells (CAPAN-2, BxPc3, and PaTu-8902) treated with a carbon monoxide-releasing molecule or its inactive counterpart, or exposed to carbon monoxide gas (500 ppm/24 h). For in vivo studies, pancreatic cancer cells (CAPAN-2/PaTu-8902) were xenotransplanted subcutaneously into athymic mice, subsequently treated with carbon monoxide-releasing molecule (35 mg/kg b.w. i.p./day), or exposed to safe doses of carbon monoxide (500 ppm 1 h/day;n = 6 in each group). Results: Both carbon monoxide-releasing molecule and carbon monoxide exposure significantly inhibited proliferation of human pancreatic cancer cells (p < 0.05). A substantial decrease in Akt phosphorylation was obse

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/LH11030" target="_blank" >LH11030: Experimental studies of potential antiproliferative effects of edible algae</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Digestive and Liver Disease

ISSN

1590-8658

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

4

Country of publishing house

IT - ITALY

Number of pages

7

Pages from-to

369-375

UT code for WoS article

000332420200015

EID of the result in the Scopus database

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