The influence of deep hypothermia on inflammatory status, tissue hypoxia and endocrine function of adipose tissue during cardiac surgery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282404" target="_blank" >RIV/00216208:11110/14:10282404 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/14:00217359 RIV/00064165:_____/14:10282404
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0011224014000406" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0011224014000406</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cryobiol.2014.02.007" target="_blank" >10.1016/j.cryobiol.2014.02.007</a>
Alternative languages
Result language
angličtina
Original language name
The influence of deep hypothermia on inflammatory status, tissue hypoxia and endocrine function of adipose tissue during cardiac surgery
Original language description
Changes in endocrine function of adipose tissue during surgery, such as excessive production of proinflammatory cytokines, can significantly alter metabolic response to surgery and worsen its outcomes and prognosis of patients. Therapeutic hypothermia has been used to prevent damage connected with perioperative ischemia and hypoperfusion. The aim of our study was to explore the influence of deep hypothermia on systemic and local inflafnmation, adipose tissue hypoxia and adipocytokine production. We compared serum concentrations of proinflammatory markers (CRP, IL-6, IL-8, sIL-2R, sTNFRI, PCT) and mRNA expression of selected genes involved in inflammatory reactions (IL-6, TNF-alpha, MCP-1, MIF) and adaptation to hypoxia and oxidative stress (HIF1-alpha,MT3, GLUT1, IRS1, GPX1, BCL-2) in subcutaneous and visceral adipose tissue and in isolated adipocytes of patients undergoing cardiosurgical operation with hypothermic period. Deep hypothermia significantly delayed the onset of surgery-re
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13299" target="_blank" >NT13299: Molecular mechanisms of subclinical inflammation in adipose tissue and its role in the etiopathogenesis of type 2 diabetes mellitus</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cryobiology
ISSN
0011-2240
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
269-275
UT code for WoS article
000334145900014
EID of the result in the Scopus database
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