Xanthomas: Clinical and pathophysiological relations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282525" target="_blank" >RIV/00216208:11110/14:10282525 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/14:10282525

Result on the web

<a href="http://biomed.papers.upol.cz/pdfs/bio/2014/02/04.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2014/02/04.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.016" target="_blank" >10.5507/bp.2014.016</a>

Result language

angličtina

Original language name

Xanthomas: Clinical and pathophysiological relations

Original language description

Background. Xanthomas are well circumscribed lesions in the connective tissue of the skin, tendons or fasciae that predominantly consist of foam cells; these specific cells are formed from macrophages as a result of an excessive uptake of low density lipoprotein (LDL) particles and their oxidative modification. Results. Until recently, xanthelasma was considered to be only a cosmetic lesion; however, according to the results of recent prospective studies it is connected with an increased cardiovascularrisk and reduced average lifespan. Pathogenetic mechanisms involved in the development of xanthomas resemble early stages of atherogenesis. In clinical practice, xanthomas can signalise various congenital or acquired dyslipidemias. The most prevalent form of xanthomas is xanthelasma palpebrarum. Tendinous and tuberous xanthomas are typical for autosomal dominant hypercholester-olemia, as well as for some rare conditions, such as cerebrotendinous xanthomatosis and familial beta-sitosterol

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

158

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

181-188

UT code for WoS article

000338628200004

EID of the result in the Scopus database

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