Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282619" target="_blank" >RIV/00216208:11110/14:10282619 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/14:10282619

Result on the web

<a href="http://dx.doi.org/10.1038/ng.3118" target="_blank" >http://dx.doi.org/10.1038/ng.3118</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ng.3118" target="_blank" >10.1038/ng.3118</a>

Result language

angličtina

Original language name

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Original language description

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of riskalleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shap

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Genetics

ISSN

1061-4036

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

1187-1196

UT code for WoS article

000344131900009

EID of the result in the Scopus database

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