Avidity of antiphospholipid antibodies - our current knowledge

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282818" target="_blank" >RIV/00216208:11110/14:10282818 - isvavai.cz</a>
Result on the web
<a href="http://www.prolekare.cz/linkout/50383" target="_blank" >http://www.prolekare.cz/linkout/50383</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Avidity of antiphospholipid antibodies - our current knowledge
Original language description
Antiphospholipid antibodies (APL), which represent serum markers of the antiphospholipid syndrome, comprise an extremely heterogeneous group of autoantibodies directed against various phospholipids and protein cofactors. The heterogeneity of APL includesnot only their antigen-binding site specificity but also their avidity. The aim of this study was to summarize the current knowledge about commonly-used procedures for the avidity determination with a special interest in the antiphospholipid antibodiesand to evaluate the clinical significance of APL avidity determination. The common techniques in clinical laboratories for avidity determination utilize the ELISAs in the presence of various chaotropic agents. The findings of clinical studies suggest that the high avidity APL are associated with thrombosis and antiphospholipid syndrom (APS). The determination of APL avidity might be a complementary laboratory marker applicable in the classification of APS.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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