Mitochondrial membrane assembly of TMEM70 protein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10283206" target="_blank" >RIV/00216208:11110/14:10283206 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00428880 RIV/00064165:_____/14:10283206
Result on the web
<a href="http://dx.doi.org/10.1016/j.mito.2014.02.010" target="_blank" >http://dx.doi.org/10.1016/j.mito.2014.02.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mito.2014.02.010" target="_blank" >10.1016/j.mito.2014.02.010</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial membrane assembly of TMEM70 protein
Original language description
Dysfunction of TMEM70 disrupts the biogenesis of ATP synthase and represents the frequent cause of autosomal recessive encephalocardiomyopathy. We used tagged forms of TMEM70 and demonstrated that it has a hairpin structure with the N- and C-termini oriented towards the mitochondrial matrix. On BN-PAGE TMEM70 was detected in multiple forms including dimers and displayed partial overlap with assembled ATP synthase. Immunoprecipitation studies confirmed mutual interactions between TMEM70 molecules but, together with immunogold electron microscopy, not direct interaction with ATP synthase subunits. This indicates that the biological function of TMEM70 in the ATP synthase biogenesis may be mediated through interaction with other protein(s).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mitochondrion
ISSN
1567-7249
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
February
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000336009600001
EID of the result in the Scopus database
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