Fermitin-3 fragmentation observed in the platelets of patients with cardiovascular diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10283500" target="_blank" >RIV/00216208:11110/14:10283500 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/14:00011075 RIV/61383082:_____/14:#0000273 RIV/00216208:11130/14:10283500 RIV/00064203:_____/14:10283500

Result on the web

<a href="http://cardiologyacademicpress.com/soap/pdf/delme_2112_53e55098040d23.99688914.pdf" target="_blank" >http://cardiologyacademicpress.com/soap/pdf/delme_2112_53e55098040d23.99688914.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Fermitin-3 fragmentation observed in the platelets of patients with cardiovascular diseases

Original language description

Platelets are essential for primary hemostasis, but they also play a key role in the development of acute coronary syndrome. Moreover, platelets also promote an inflammatory reaction connected with atherosclerosis. The aim of this pilot study was to search for platelet proteome changes in a patient cohort with cardiovascular diseases, in comparison with a group of young healthy donors. 23 platelet samples (patients with acute coronary syndrome n=8, patients with stable angina pectoris n=7, and control group n=8) were used in this work. Platelets were isolated by centrifugation, and platelet proteins were separated using 2D SDS-PAGE. Proteins were identified and further analyzed using nanoLC-MS/MS. In total, 33 spots were observed to differ significantly between the studied groups; they corresponded to 53 different proteins. The proteome changes were found to be identical or closely related to the platelet proteome changes induced by platelet activation. Fragmentation of fermitin family

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

<a href="/en/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiophotonics for future health care</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and Clinical Cardiology

ISSN

1205-6626

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

8

Country of publishing house

CA - CANADA

Number of pages

5

Pages from-to

2881-2885

UT code for WoS article

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EID of the result in the Scopus database

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