Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284199" target="_blank" >RIV/00216208:11110/14:10284199 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10284199 RIV/00064203:_____/14:10284199 RIV/00064165:_____/14:10284199
Result on the web
<a href="http://www.prolekare.cz/linkout/50423" target="_blank" >http://www.prolekare.cz/linkout/50423</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms
Original language description
Our present study was aimed to investigate time-profile kinetics of interleukins, vascular endothelial growth factor (VEGF) in acute inflammatory response following traumatic brain injury, and the influence of activated microglial cells in patients who developed severe space occupying lesion (SOL) of secondary traumatic brain injury. Interleukins IL-6, monocyte chemo attractant protein (MCP-1), and VEGF had a significant different time-profile kinetics (p<0.05) in patient with, and without expansive traumatic brain contusions (SOL). The serum VEGF was significantly higher in trauma patients with uncomplicated brain contusions, and lower in patients with SOL. The patients with septic complications developed the sudden increase of TNF alpha and IL-8 within the first 72 hours. Our data suggested PSGL and CD68 immunopositivity of microglial cells in both focal and diffuse TBI, predominantly in perivascular space correlated with telolysosome formation in cytoplasma. Polymorphism of PAI-1, M
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Česko-slovenská patologie a Soudní lékařství
ISSN
1210-7875
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
40-47
UT code for WoS article
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EID of the result in the Scopus database
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