Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284445" target="_blank" >RIV/00216208:11110/14:10284445 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00439233 RIV/00216208:11310/14:10284445 RIV/00064211:_____/14:#0000321

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2014_050" target="_blank" >http://dx.doi.org/10.4149/neo_2014_050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2014_050" target="_blank" >10.4149/neo_2014_050</a>

Result language

angličtina

Original language name

Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium

Original language description

The most common malignancies of the female genital tract are endometrial carcinomas, whose are generally proceeded by hyperplasia. The maintenance of tissue homeostasis is to great extent governed by apoptosis, whose defects can lead to the preneoplasticand/or cancerous changes. Endometrial apoptosis involves among others three groups of proteins of the Bcl-2 family. First group contains anti-apoptotic proteins (e. g. Bcl-2, Bcl-xL). The other two groups belong to the pro-apoptotic proteins with three(e. g. Bax, Bak) or one (e. g. Bad, Bid) so-called BH domains. Bad and Bid trigger the oligomerization of Bak and Ban protein, which permeabilize the outer mitochondrial wall. Unlike Bid, Bad cannot directly trigger apoptosis. Instead, Bad lowers the threshold at which apoptosis is induced, by binding anti-apoptotic Bcl-2 proteins. However, their mutual counterbalance or synergism in the human endometrium has not been reported yet. In this study, the levels of Bid and Bad were measured u

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

<a href="/en/project/GAP207%2F12%2F0919" target="_blank" >GAP207/12/0919: The role of hydrophobic plasma membrane interior in DOR regulation of trimeric G protein activity</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

5

Pages from-to

411-415

UT code for WoS article

000342881700005

EID of the result in the Scopus database

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