A synthetic PPAR-gamma agonist triterpenoid ameliorates experimental fibrosis: PPAR-gamma-independent suppression of fibrotic responses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284488" target="_blank" >RIV/00216208:11110/14:10284488 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1136/annrheumdis-2012-202716" target="_blank" >http://dx.doi.org/10.1136/annrheumdis-2012-202716</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/annrheumdis-2012-202716" target="_blank" >10.1136/annrheumdis-2012-202716</a>
Alternative languages
Result language
angličtina
Original language name
A synthetic PPAR-gamma agonist triterpenoid ameliorates experimental fibrosis: PPAR-gamma-independent suppression of fibrotic responses
Original language description
The PPAR-gamma agonist triterpenoid CDDO attenuates fibrogenesis by antagonistically targeting canonical TGF-Beta/Smad and Akt signalling in a PPAR-gamma- independent manner. These findings identify this synthetic triterpenoid as a potential new therapyfor the control of fibrosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of the Rheumatic Diseases
ISSN
0003-4967
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
446-454
UT code for WoS article
000329488000003
EID of the result in the Scopus database
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