Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284516" target="_blank" >RIV/00216208:11110/14:10284516 - isvavai.cz</a>

Result on the web

<a href="http://www.biomedcentral.com/content/pdf/s13075-014-0454-8.pdf" target="_blank" >http://www.biomedcentral.com/content/pdf/s13075-014-0454-8.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13075-014-0454-8" target="_blank" >10.1186/s13075-014-0454-8</a>

Result language

angličtina

Original language name

Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

Original language description

Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We have investigated expression of the receptors for BAFF in muscle tissue and found their association toserum autoantibodies and muscle expression of type-I IFN markers. The expression pattern of receptors for BAFF on B and plasma cells in muscle suggests a possible local role for BAFF in autoantibody production in muscle tissues of patients with myositiswho have anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arthritis Research and Therapy

ISSN

1478-6354

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

000349885900033

EID of the result in the Scopus database

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