Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284668" target="_blank" >RIV/00216208:11110/14:10284668 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10284668
Result on the web
<a href="http://dx.doi.org/10.1056/NEJMoa1315878" target="_blank" >http://dx.doi.org/10.1056/NEJMoa1315878</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1056/NEJMoa1315878" target="_blank" >10.1056/NEJMoa1315878</a>
Alternative languages
Result language
angličtina
Original language name
Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
Original language description
BackgroundElevated lipoprotein-associated phospholipase A(2) activity promotes the development of vulnerable atherosclerotic plaques, and elevated plasma levels of this enzyme are associated with an increased risk of coronary events. Darapladib is a selective oral inhibitor of lipoprotein-associated phospholipase A(2). MethodsIn a double-blind trial, we randomly assigned 15,828 patients with stable coronary heart disease to receive either once-daily darapladib (at a dose of 160 mg) or placebo. The primary end point was a composite of cardiovascular death, myocardial infarction, or stroke. Secondary end points included the components of the primary end point as well as major coronary events (death from coronary heart disease, myocardial infarction, or urgent coronary revascularization for myocardial ischemia) and total coronary events (death from coronary heart disease, myocardial infarction, hospitalization for unstable angina, or any coronary revascularization). ResultsDuring a median
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
New England Journal of Medicine
ISSN
0028-4793
e-ISSN
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Volume of the periodical
370
Issue of the periodical within the volume
18
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1702-1711
UT code for WoS article
000335405200008
EID of the result in the Scopus database
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