DNA methylation markers for early detection of women's cancer: promise and challenges

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284747" target="_blank" >RIV/00216208:11110/14:10284747 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/14:10284747

Result on the web

<a href="http://dx.doi.org/10.2217/EPI.14.20" target="_blank" >http://dx.doi.org/10.2217/EPI.14.20</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/EPI.14.20" target="_blank" >10.2217/EPI.14.20</a>

Result language

angličtina

Original language name

DNA methylation markers for early detection of women's cancer: promise and challenges

Original language description

Breast, ovarian and endometrial cancers cause significant morbidity and mortality. Despite the presence of existing screening, diagnostic and treatment modalities, they continue to pose considerable unsolved challenges. Overdiagnosis is a growing problemin breast cancer screening and neither screening nor early diagnosis of ovarian or endometrial cancer is currently possible. Moreover, treatment of the diversity of these cancers presenting in the clinic is not sufficiently personalized at present. Recent technological advances, including reduced representation bisulfite sequencing, methylation arrays, digital PCR, next-generation sequencing and advanced statistical data analysis, enable the analysis of methylation patterns in cell-free tumor DNA in serum/plasma. Ongoing work is bringing these methods together for the analysis of samples from large clinical trials, which have been collected well in advance of cancer diagnosis. These efforts pave the way for the development of a noninva

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

<a href="/en/project/7E13033" target="_blank" >7E13033: Epigenetics for female personalized cancer care</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epigenomics

ISSN

1750-1911

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

17

Pages from-to

311-327

UT code for WoS article

000340668300013

EID of the result in the Scopus database

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