Steroid profiling in pregnancy: A focus on the human fetus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284808" target="_blank" >RIV/00216208:11110/14:10284808 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/14:#0000456 RIV/00064165:_____/14:10284808 RIV/00216275:25310/14:39898083
Result on the web
<a href="http://dx.doi.org/10.1016/j.jsbmb.2013.03.008" target="_blank" >http://dx.doi.org/10.1016/j.jsbmb.2013.03.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jsbmb.2013.03.008" target="_blank" >10.1016/j.jsbmb.2013.03.008</a>

Result language
angličtina
Original language name
Steroid profiling in pregnancy: A focus on the human fetus
Original language description
In this review we focused on steroid metabolomics in human fetuses and newborns and its role in the physiology and pathophysiology of human pregnancy and subsequent stages of human life, and on the physiological relevance of steroids influencing the nervous systems with regards to their concentrations in the fetus. Steroid profiling provides valuable data for the diagnostics of diseases related to altered steroidogenesis in the fetal and maternal compartments and placenta. We outlined a potential use ofsteroid metabolomics for the prediction of reproductive disorders, misbalance of hypothalamic-pituitary-adrenal axis, and impaired insulin sensitivity in subsequent stages of human life. A possible role of steroids exhibiting a non-genomic effect in thedevelopment of gestational diabetes and in the neuroprotection via negative modulation of AMPA/kainate receptors was also indicated. Increasing progesterone synthesis and catabolism, declining production of tocolytic 5 beta-pregnane ster
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Project
<a href="/en/project/NT11513" target="_blank" >NT11513: Profiling of neurosteroid conjugates and other acidic metabolites in body fluids and their perspective in clinical diagnostics</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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