Progesterone, inflammation and preterm labor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285102" target="_blank" >RIV/00216208:11110/14:10285102 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/14:#0000472 RIV/00064165:_____/14:10285102
Result on the web
<a href="http://dx.doi.org/10.1016/j.jsbmb.2013.02.008" target="_blank" >http://dx.doi.org/10.1016/j.jsbmb.2013.02.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jsbmb.2013.02.008" target="_blank" >10.1016/j.jsbmb.2013.02.008</a>

Result language
angličtina
Original language name
Progesterone, inflammation and preterm labor
Original language description
The initiation of human parturition is not fully understood to date. The data from animal experiments demonstrate that the primary impulse for the initiation of physiological labor arises from the fetal hypothalamo-pituitary-adrenal axis (HPA). HPA is responsible for the stimulation of steroid synthesis and prostaglandin production and, in turn, the cervical dilation and the beginning of myometrial contractions. Animal experiments, however, are only partly suitable for understanding the mechanism of human labor due to substantial species-specificity. In human, the changing levels of placental CRH control the production of fetal and placental steroids. The fundamental pathogenic manifestation of spontaneous preterm labor is inflammation and similar processes also underlie the full term one. While in full term labor it is not yet precisely known what starts this process, in the preterm one, several factors have been discussed like infection, uteroplacental ischemia, and hormonal abnormal
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Project
<a href="/en/project/NT12211" target="_blank" >NT12211: Prediction of termination of pregnancy in women with serious hepatopathies</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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