Statin-Associated Myopathy: From Genetic Predisposition to Clinical Management

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285465" target="_blank" >RIV/00216208:11110/14:10285465 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/14:00059067 RIV/00064165:_____/14:10285465
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_S327.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_S327.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Statin-Associated Myopathy: From Genetic Predisposition to Clinical Management
Original language description
Statin-associated myopathy (SAM) represents a broad spectrum of disorders from insignificant myalgia to fatal rhabdomyolysis. Its frequency ranges from 1-5 % in clinical trials to 15-20 % in everyday clinical practice. To a large extent, these variationscan be explained by the definition used. Thus, we propose a scoring system to classify statin-induced myopathy according to clinical and biochemical criteria as 1) possible, 2) probable or 3) definite. The etiology of this disorder remains poorly understood. Most probably, an underlying genetic cause is necessary for overt SAM to develop. Variants in a few gene groups that encode proteins involved in: i) statin metabolism and distribution (e.g. membrane transporters and enzymes; OATP1B1, ABCA1, MRP, CYP3A4), ii) coenzyme Q10 production (e.g. COQ10A and B), iii) energy metabolism of muscle tissue (e.g. PYGM, GAA, CPT2) and several others have been proposed as candidates which can predispose to SAM. Pharmacological properties of individu
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/NT11307" target="_blank" >NT11307: Analysis of the genetic predisposition to the statin-induced side effects</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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