The effect of Vancomycin degradation products in the topical treatment of osteomyelitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10286541" target="_blank" >RIV/00216208:11110/14:10286541 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10286541 RIV/00064203:_____/14:10286541

Result on the web

<a href="http://dx.doi.org/10.4149/BLL_2014_154" target="_blank" >http://dx.doi.org/10.4149/BLL_2014_154</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2014_154" target="_blank" >10.4149/BLL_2014_154</a>

Result language

angličtina

Original language name

The effect of Vancomycin degradation products in the topical treatment of osteomyelitis

Original language description

The topical application of Vancomycin is increasingly being used in orthopedics because of the development of methicillin resistant bacteria. Consequently, resistance to Vancomycin has recently been on the rise. One possible explanation for this phenomenon could be the thermal degradation of Vancomycin to antibacterially inactive crystalline degradation products (CDP-1s).In our experiment in vitro the CDP-1s and the factor B (active form) released from bone grafts into the buffer solution were measuredusing the HPLC at progressive intervals. The CDP-1 levels kept increasing until the end of measurement on day 15, when the concentration of CDP-1s (1280.7 mg/L) was much higher compared to that of factor B (217.5 mg/L). We confirmed the tendency of Vancomycin to convert to antimicrobially ineffective CDP-1s. Although Vancomycin is decomposed into crystalline degradation products, its active forms are released from bone grafts in sufficient concentration for more than two weeks.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FI - Traumatology and orthopaedics

OECD FORD branch

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Project

<a href="/en/project/NT14218" target="_blank" >NT14218: Use of antimicrobial peptides to treatment of musculoskeletal infections with the help of local carriers used in orthopedics</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

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Volume of the periodical

115

Issue of the periodical within the volume

12

Country of publishing house

SK - SLOVAKIA

Number of pages

4

Pages from-to

796-799

UT code for WoS article

000348244100013

EID of the result in the Scopus database

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