CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10287124" target="_blank" >RIV/00216208:11110/14:10287124 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10287124 RIV/61989592:15110/14:33149843 RIV/00064203:_____/14:10287124 RIV/00064165:_____/14:10287124
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2013.354" target="_blank" >http://dx.doi.org/10.1038/leu.2013.354</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2013.354" target="_blank" >10.1038/leu.2013.354</a>

Result language
angličtina
Original language name
CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage
Original language description
Switches from the lymphoid to myeloid lineage during B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment are considered rare and thus far have been detected in MLL-rearranged leukemia. Here, we describe a novel BCP-ALL subset, switching BCP-ALL or swALL, which demonstrated monocytosis early during treatment. Despite their monocytic phenotype, 'monocytoids' share immunoreceptor gene rearrangements with leukemic B lymphoblasts. All swALLs demonstrated BCP-ALL with CD2 positivity and no MLL alterations, and the proportion of swALLs cases among BCP-ALLs was unexpectedly high (4%). The upregulation of CEBPa and demethylation of the CEBPA gene were significant in blasts at diagnosis, prior to the time when most of the switching occurs. Intermediate stages between CD14(neg)CD19(pos)CD34(pos) B lymphoblasts and CD14(pos)CD19(neg)CD34(neg) 'monocytoids' were detected, and changes in the expression of PAX5, PU1, M-CSFR, GM-CSFR and other genes accompanied the switch. Alterations in
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)