Importance of Cerebral Folate Deficiency for Development and Treatment of Autism Spectrum Disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10287960" target="_blank" >RIV/00216208:11110/14:10287960 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/14:10287960 RIV/00216208:11130/14:10287960
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Importance of Cerebral Folate Deficiency for Development and Treatment of Autism Spectrum Disorder
Original language description
Autism or Autism Spectrum Disorders (ASD) is serious lifelong neurobehavioral impairment, significantly complicating the integration of an individual into the normal life. Etiology of ASD is usually complex combination of different disturbances, and remains unknown in a majority of cases. Cerebral Folate Deficiency (CFD) is a neurodegenerative syndrome characterized by reduced concentrations of metabolically active folate in cerebrospinal fluid (CSF) and normal serum levels in most cases. While a serious CFD can be easily diagnosed because of presence of obvious motor and sensory impairment, a mild CFD can play a role in the development of various behavioral disabilities including ASD with no apparent physical disability. Severity of CFD is highly variable. The CFD is usually partially, rarely completely, compensable syndrome and some publications reported also positive therapeutic effect on the core ASD symptoms (impaired communication, social interaction, abstraction and stereotypic
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
IN - Informatics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14200" target="_blank" >NT14200: Identification of genetic defects in families of patients with autism</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal on Biomedicine and Healthcare
ISSN
1805-8698
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
9-18
UT code for WoS article
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EID of the result in the Scopus database
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