Microbiome and Colorectal Carcinoma Insights From Germ-Free and Conventional Animal Models
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10292189" target="_blank" >RIV/00216208:11110/14:10292189 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/14:00435686
Result on the web
<a href="http://dx.doi.org/10.1097/PPO.0000000000000052" target="_blank" >http://dx.doi.org/10.1097/PPO.0000000000000052</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PPO.0000000000000052" target="_blank" >10.1097/PPO.0000000000000052</a>
Alternative languages
Result language
angličtina
Original language name
Microbiome and Colorectal Carcinoma Insights From Germ-Free and Conventional Animal Models
Original language description
The mammalian microbiota plays a crucial role in the pathogenesis of many diseases. Thanks to recent advances in metagenomics, proteomics, and metabolomics, microbiome composition and metabolic activity can now be studied in detail. Results obtained by such fascinating and provocative studies would be meaningless without considering the perspective of the whole organism. Our work using gnotobiology as the major tool to unravel the mechanisms of host-microbe interaction has demonstrated the crucial roleof microbiota in the initiation and progression of inflammation-associated colorectal neoplasia. Carcinogenesis in the gut is driven by the presence of potentially harmful microbes or by lack of protective ones, by the production of carcinogens generatedby microbes, and by the induction of inflammation and modulation of the immune system. Here, we review these mechanisms with special emphasis on those where gnotobiology has yielded important insights.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Journal
ISSN
1528-9117
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
217-224
UT code for WoS article
000337708000010
EID of the result in the Scopus database
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