Metabolic Gene Variants Associated with Chromosomal Aberrations in Healthy Humans

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294514" target="_blank" >RIV/00216208:11110/15:10294514 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/15:00452304 RIV/00216208:11130/15:10294514 RIV/75010330:_____/15:00010780

Result on the web

<a href="http://dx.doi.org/10.1002/gcc.22239" target="_blank" >http://dx.doi.org/10.1002/gcc.22239</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/gcc.22239" target="_blank" >10.1002/gcc.22239</a>

Result language

angličtina

Original language name

Metabolic Gene Variants Associated with Chromosomal Aberrations in Healthy Humans

Original language description

Nonspecific chromosomal aberrations (CAs) are found in about 1% of lymphocytes drawn from healthy individuals. They include chromosome-type aberrations (CSAs), which are increased in exposure to ionizing radiation, and chromatid-type aberrations (CTAs) which in experimental systems are formed by DNA binding carcinogens and mutagens. The frequency of CAs is associated with the risk of cancer, but the causes of CAs in general population are unknown. Here, we want to test whether variants in metabolic genes associate with CAs in healthy volunteers. Cases were considered those whose total CA (CAtot) frequency was >2% and for CSA and CTA the limit was >1%. Controls had lower frequencies of CAs. Functional polymorphisms in seven genes were selected for analysis: cytochrome P450 1B1 (CYP1B1), epoxide hydrolase 1 (EPHX1), NAD(P)H:quinone oxidoreductase 1 (NQO1), each coding for phase 1 enzymes, and glutathione S-transferase P1 (GSTP1), glutathione S-transferases M1 (GSTM1) and T1 (GSTT1), codi

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genes Chromosomes and Cancer

ISSN

1045-2257

e-ISSN

—

Volume of the periodical

54

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

260-266

UT code for WoS article

000350275900006

EID of the result in the Scopus database

2-s2.0-84923229952