High levels of metastasis-inducing S100A4 protein and treatment outcome in early rheumatoid arthritis: data from the PERAC cohort
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294685" target="_blank" >RIV/00216208:11110/15:10294685 - isvavai.cz</a>
Alternative codes found
RIV/60456540:_____/15:#0000772 RIV/00023728:_____/15:#0005037
Result on the web
<a href="http://dx.doi.org/10.3109/1354750X.2014.989544" target="_blank" >http://dx.doi.org/10.3109/1354750X.2014.989544</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/1354750X.2014.989544" target="_blank" >10.3109/1354750X.2014.989544</a>
Alternative languages
Result language
angličtina
Original language name
High levels of metastasis-inducing S100A4 protein and treatment outcome in early rheumatoid arthritis: data from the PERAC cohort
Original language description
The aim of this study was to evaluate the role of S100A4 as a biomarker in patients with early rheumatoid arthritis (RA). S100A4 levels were measured in 59 patients with early RA and in 41 healthy controls. The association between the S100A4 levels and the treatment outcome after 12 months was determined using multivariate regression analysis. Serum S100A4 levels were significantly higher in the patients with early RA than in the healthy subjects and significantly decreased after 3 months of treatment.Diseases activity at 12 months was significantly higher in female patients who had initially high levels of S100A4. Persistently high S100A4 levels predicted poor treatment outcome and S100A4 may thus represent promising biomarker for assessing treatmentresponse in patients with RA.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomarkers
ISSN
1354-750X
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
47-51
UT code for WoS article
000348369500007
EID of the result in the Scopus database
2-s2.0-84921755699