Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294800" target="_blank" >RIV/00216208:11110/15:10294800 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10294800
Result on the web
<a href="http://dx.doi.org/10.1186/s12967-015-0429-9" target="_blank" >http://dx.doi.org/10.1186/s12967-015-0429-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12967-015-0429-9" target="_blank" >10.1186/s12967-015-0429-9</a>

Result language
angličtina
Original language name
Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model
Original language description
Mild therapeutic hypothermia (MTH) is being used after cardiac arrest for its expected improvement in neurological outcome. Safety of MTH concerning inducibility of malignant arrhythmias has not been satisfactorily demonstrated. This study compares inducibility of ventricular fibrillation (VF) before and after induction of MTH in a whole body swine model and evaluates possible interaction with changing potassium plasma levels. Methods: The extracorporeal cooling was introduced in fully anesthetized swine (n = 6) to provide MTH. Inducibility of VF was studied by programmed ventricular stimulation three times in each animal under the following: during normothermia (NT), after reaching the core temperature of 32 degrees C (HT) and after another 60 minutesof stable hypothermia (HT60). Inducibility of VF, effective refractory period of the ventricles (ERP), QTc interval and potassium plasma levels were measured. Results: Starting at normothermia of 38.7 (IQR 38.2; 39.8)degrees C, HT was ac
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—

Project
<a href="/en/project/NT14160" target="_blank" >NT14160: Restenoses of dialysis vascular access: quantification, understanding the etiology and the effectiveness of modern percutaneous therapy</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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