Kynurenine and uric acid levels in chronic myeloid leukemia patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294984" target="_blank" >RIV/00216208:11110/15:10294984 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/15:10294984 RIV/00179906:_____/15:10294984 RIV/00064165:_____/15:10294984

Result on the web

<a href="http://www.tandfonline.com/doi/full/10.4161/2162402X.2014.992646" target="_blank" >http://www.tandfonline.com/doi/full/10.4161/2162402X.2014.992646</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/2162402X.2014.992646" target="_blank" >10.4161/2162402X.2014.992646</a>

Result language

angličtina

Original language name

Kynurenine and uric acid levels in chronic myeloid leukemia patients

Original language description

Indoleamine 2,3-dioxygenase 1 (IDO1), IDO2 and tryptophan 2,3-dioxygenase (TDO) represent some of the key immune regulators. Their increased activity has been demonstrated in a number of human malignancies but not yet in chronic myeloid leukemia (CML). In the present study, the activity of these enzymes was tested in 29 CML patients and 28 healthy subjects by monitoring the kynurenine (KYN)/tryptophan ratio. Serum samples taken prior to the therapy displayed a highly significant difference in KYN levelsbetween the patient and control groups. However, increased KYN levels were detected in only 13 (44.8%) of these CML patients. The KYN levels in pretreatment sera of the patients correlated with the tumor burden. There was also a strong correlation between KYN levels and uric acid levels (UA). This suggests but does not prove the possible involvement of UA in activating IDO family of enzymes. Whenever tested, the increased KYN levels normalized in the course of the therapy. Patients with

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT12363" target="_blank" >NT12363: Knowledge deepening on immunology of chronic myeloid leukemia: necessary precondition of future terapeutic vaccine</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

OncoImmunology

ISSN

2162-402X

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000352612900027

EID of the result in the Scopus database

2-s2.0-84924310773