Is copper imbalance an environmental factor influencing keratoconus development?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294994" target="_blank" >RIV/00216208:11110/15:10294994 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10294994
Result on the web
<a href="http://dx.doi.org/10.1016/j.mehy.2015.02.017" target="_blank" >http://dx.doi.org/10.1016/j.mehy.2015.02.017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mehy.2015.02.017" target="_blank" >10.1016/j.mehy.2015.02.017</a>

Result language
angličtina
Original language name
Is copper imbalance an environmental factor influencing keratoconus development?
Original language description
Keratoconus is a bilateral disease characterized by progressive corneal thinning leading to irregular astigmatism that results in significant visual impairment. Despite extensive research, the exact etiopathogenesis of keratoconus remains unknown. Many copper-dependent enzymes such as superoxide dismutases, cytochrome c oxidase and lysyl oxidase have been shown to be altered in keratoconic corneas, and a decrease of copper levels in the diseased tissue has been reported as well. We propose a hypothesislinking all the putative pathways of keratoconus development and suggest that copper imbalance in corneal tissue may be an independent risk factor for the disease. The assessment of copper levels and its distribution in keratoconic corneas warrants further investigation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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