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Isoelectric Focusing of Serum Apolipoprotein C-III as a Sensitive Screening Method for the Detection of O-glycosylation Disturbances

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295581" target="_blank" >RIV/00216208:11110/15:10295581 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/15:10295581

  • Result on the web

    <a href="http://pmr.lf1.cuni.cz/media/pdf/pmr_2015116020073.pdf" target="_blank" >http://pmr.lf1.cuni.cz/media/pdf/pmr_2015116020073.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14712/23362936.2015.48" target="_blank" >10.14712/23362936.2015.48</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Isoelectric Focusing of Serum Apolipoprotein C-III as a Sensitive Screening Method for the Detection of O-glycosylation Disturbances

  • Original language description

    Apolipoprotein C-III (ApoC-III) is a glycoprotein carrying the most common O-linked glycan structure and is abundantly present in serum, what renders it a suitable marker for analysis of O-glycosylation abnormalities. Isoelectric focusing followed by a Western blot of ApoC-III, using PhastSystemTM Electrophoresis System (GE Healthcare), was introduced as a rather simple and rapid method for screening of certain subtypes of inherited glycosylation disorders. The study's aim was to establish this method in our laboratory, what included performing the analysis in a group of 170 healthy individuals to set the reference range of detected relative amounts of sialylated ApoC-III isoforms and to evaluate the gender- and age-dependent differences. A significantrelative increase of asialo-ApoC-III with growing age was found. Secondly, we examined serum from patients with selected metabolic disorders and detected minor O-glycosylation changes in diseases such as Prader-Willi syndrome, PGM1 (phos

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FG - Paediatrics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT12166" target="_blank" >NT12166: The study of the bases of congenital disorders of glycosylation</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Prague medical report

  • ISSN

    1214-6994

  • e-ISSN

  • Volume of the periodical

    116

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    14

  • Pages from-to

    73-86

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-84938944596