Early magnetic resonance imaging predictors of clinical progression after 48months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295612" target="_blank" >RIV/00216208:11110/15:10295612 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/15:10295612

Result on the web

<a href="http://dx.doi.org/10.1111/ene.12716" target="_blank" >http://dx.doi.org/10.1111/ene.12716</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ene.12716" target="_blank" >10.1111/ene.12716</a>

Result language

angličtina

Original language name

Early magnetic resonance imaging predictors of clinical progression after 48months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a

Original language description

Background and purposeOur aim was to identify early imaging surrogate markers of clinical progression in patients after the first demyelinating event suggestive of multiple sclerosis treated with weekly intramuscular interferon -1a. In a prospective observational study, the predictive role of baseline and 6-month changes in magnetic resonance imaging outcomes was investigated with respect to relapse activity and development of confirmed disability progression in patients after 48months. MethodsThis study examined 210 patients. Multivariate Cox proportional hazard models were used to analyse predictors of relapse activity and confirmed disability progression after 48months. ResultsGreater T2 lesion volume [hazard ratio (HR) 1.81; P=0.005] and the presence of contrast-enhancing lesions (HR 2.13; P<0.001) at baseline were significantly associated with increased cumulative risk of a second clinical attack over 48months. A greater decrease of the corpus callosum volume (HR 2.74; P=0.001) an

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Neurology

ISSN

1351-5101

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1113-1123

UT code for WoS article

000356090800014

EID of the result in the Scopus database

2-s2.0-84930758628