The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295613" target="_blank" >RIV/00216208:11110/15:10295613 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10295613
Result on the web
<a href="http://dx.doi.org/10.1016/j.jtemb.2014.05.007" target="_blank" >http://dx.doi.org/10.1016/j.jtemb.2014.05.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jtemb.2014.05.007" target="_blank" >10.1016/j.jtemb.2014.05.007</a>

Result language
angličtina
Original language name
The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases
Original language description
Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger neurodegeneration through various mechanisms, notably induction of oxidative stress, promotion of a-synuclein aggregation and fibril formation, activation of microglial cells leading to inflammation and impaired production of metalloproteins. In this article we review available studies concerning Fe, Cu and Mn in Parkinson's disease and Wilson's disease. In Parkinson's disease local dysregulation of iron metabolism in thesubstantia nigra (SN) seems to be related to neurodegeneration with an increase in SN iron concentration, accompanied by decreased SN Cu and ceruloplasmin concentrations and increased free Cu concentrations and decreased ferroxidase activity in the cerebrospinal fluid. Available data in Wilson's disease suggest that substantial increases in CNS Cu concentrations persist for a long time during chelating treatment and that local accumulation of Fe in certain brain nuclei may occur during
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/7F14308" target="_blank" >7F14308: Comparative study of Huntington's disease using biochemical, immunocytochemical and molecular genetic methods on the mouse, minipig and human tissues and cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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