Soy and Breast Cancer: Focus on Angiogenesis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295616" target="_blank" >RIV/00216208:11110/15:10295616 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3390/ijms160511728" target="_blank" >http://dx.doi.org/10.3390/ijms160511728</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms160511728" target="_blank" >10.3390/ijms160511728</a>

Result language
angličtina
Original language name
Soy and Breast Cancer: Focus on Angiogenesis
Original language description
Epidemiological studies have revealed that high consumption of soy products is associated with low incidences of hormone-dependent cancers, including breast and prostate cancer. Soybeans contain large amounts of isoflavones, such as the genistein and daidzain. Previously, it has been demonstrated that genistein, one of the predominant soy isoflavones, can inhibit several steps involved in carcinogenesis. It is suggested that genistein possesses pleiotropic molecular mechanisms of action including inhibition of tyrosine kinases, DNA topoisomerase II, 5-reductase, galectin-induced G(2)/M arrest, protein histidine kinase, and cyclin-dependent kinases, modulation of different signaling pathways associated with the growth of cancer cells (e.g., NF-B, Akt, MAPK), etc. Moreover, genistein is also a potent inhibitor of angiogenesis. Uncontrolled angiogenesis is considered as a key step in cancer growth, invasion, and metastasis. Genistein was found to inhibit angiogenesis through regulation of
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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