Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295802" target="_blank" >RIV/00216208:11110/15:10295802 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/15:#0000396 RIV/00216208:11130/15:10295802 RIV/00064165:_____/15:10295802

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2015_056" target="_blank" >http://dx.doi.org/10.4149/neo_2015_056</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2015_056" target="_blank" >10.4149/neo_2015_056</a>

Result language

angličtina

Original language name

Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer

Original language description

Trefoil factor family (TFF) is composed of three secretory proteins (TFF1, TFF2 and TFF3) that play an important role in mucosal protection of gastrointestinal tract. Their overexpression in colorectal tumors seems to be associated with more aggressive disease. We collected serum samples from 79 healthy controls and 97 patients with metastatic colorectal cancer at the time of diagnosis or at progression. Serum levels of TTF1-3, CEA and CA19-9 were measured by ELISA. Serum TFF I and TFF3 levels were significantly higher in patients with colorectal cancer compared to healthy controls (p < 0.0001). Moreover, serum levels of TFF3 correlated with extent of liver involvement in patient without pulmonary metastases and patients with higher TFF3 levels had significantly worse outcome (p < 0.0001). Compared to CEA and CA19-9, TFF3 had higher sensitivity and the same specificity Our results indicate that TFF3 is an effective biomarker in patients with metastatic colorectal cancer with higher sen

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

3

Country of publishing house

SK - SLOVAKIA

Number of pages

8

Pages from-to

470-477

UT code for WoS article

000357705300016

EID of the result in the Scopus database

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